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Additionally, to overcome the variable pharmacokinetic limitations of SFN administration, natural and synthetic compounds incorporating SFN moiety/active functional groups can be optimized and formulated into different drug delivery systems, such as liposomes, micelles, and nano emulsions and nanoparticles, which could result in a more targeted and selective delivery in pre-cancerous or cancerous tissues and better safety outcomes
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Kononov SU et al
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PloS One (2017) 12(6):e0178879
PMID: 28164076 4 Primary carnitine deficiency - diagnosis after heart transplantation: better late than never
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