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In head-to-head trials, tirzepatide produced 20-22% weight loss compared to semaglutide's 15-18% across similar timeframes
Retatrutide has the higher observed ceiling, a mechanistically broader target profile, and two network meta-analyses that point in its direction 20 21
The CDC recommends 150 minutes per day of moderate activity paired with 2 days per week of strength-building activity or 75 minutes per week of strenuous activity, paired with strength-building
TRIUMPH-1: The Pivotal General Obesity Trial (May 2026) TRIUMPH-1 is the most important trial in the program for FDA purposes
Im just surprised that it seems more acute and why it hadnt happened prior
Dementia and cognitive function Observational studies have found an association between high homocysteine levels and increased incidence of dementia and Alzheimers disease
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