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Moreover, Gpx4 has been shown recently to modulate ferroptotic cancer cell death, a specific form of cell death characterized by the production of iron-dependent ROS generation (Yang et al., 2014)

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GHS-R1a (Growth Hormone Secretagogue Receptor type 1a): A G protein-coupled receptor activated endogenously by ghrelin, a 28-amino-acid peptide produced primarily in the stomach

AKG is also a precursor of glutamine and glutamate, which stimulate protein synthesis

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The incidence appears comparable, in the range of 2% to 5%, though direct head-to-head comparisons are lacking