tirzepatide updates once weekly for the treatment of obesity journal club Maintenance Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN - Horn - 2025 FDA approval for Zepbound (tirzepatide)

Tirzepatide and diarrhea Diarrhea affects 1223% of people on tirzepatide, with the higher end of that range coming from the SURMOUNT obesity trials at higher doses

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Participants received the maximum tolerated dose of either medication for 72 weeks

GLP-1, secreted by the intestine, brainstem, and pancreas, also exerts appetite-suppressing and gastric emptying-delaying effects on the hypothalamus

Unfortunately, especially as we age, there are aspects of our performance that we cant control, it doesnt matter how hard we train or how determined we are to succeed

If more than 2 days have passed, then the patient should skip the missed dose and administer the next dose on the regularly scheduled day