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Initially described as a mediator of exercise-induced browning of white adipose tissue and increased energy expenditure, irisin was proposed as a candidate exercise- associated signaling molecule (Bostrm et al., 2012)
Tirzepatide tablets are not a short-term fix for weight loss
SURMOUNT-1 demonstrated 15%, 19.5%, and 20.9% body weight reduction at 5, 10, and 15 mg respectively over 72 weeks FDA approvals : Mounjaro (T2D, May 2022) and Zepbound (obesity, November 2023) Cardiovascular outcomes : SURPASS-CVOT in progress to evaluate cardiovascular safety and efficacy Global availability : Approved in US, EU, and numerous international markets Side Effects and Safety Comparison# Mazdutide Side Effects# GI effects : Nausea, diarrhea, and vomiting consistent with GLP-1 class
Who Should Evaluate GLP-1 Use in Hashimoto's and What to Discuss Patients with Hashimoto's who are candidates for GLP-1 therapy must have separate clinical indication (obesity, type 2 diabetes, cardiovascular risk) and stable thyroid disease controlled on levothyroxine
Inflammopharmacology , 31 (5), 21732199
Common side effects include injection site reactions and water retention
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