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15 Studies have indicated that GLP-1R KO mice exhibit greater numbers of osteoclasts and greater bone resorption than wild-type controls

Reported Adverse Effects Reported adverse effects from online forums cited in a 2025 systematic review (PMC12313605) included: Anxiety and panic attacks Depression and anhedonia Insomnia Heart palpitations Fatigue and weakness Loss of appetite These anecdotal reports cannot be verified as directly caused by BPC-157 versus contamination, incorrect dosing, or concurrent conditions, but they raise concerns that the peptide might paradoxically worsen mental health in some individuals

Ive stopped it a couple times here and there, but after week 2-3 Im reminded why Im taking it when my real appetite starts coming back

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