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It can also help to improve the tumor microenvironment by activating the nicotinamide adenine phosphate dinucleotide (NADPH) oxidase system and producing reactive oxygen species (ROS)

The next phase of GLP-1 development will no longer be defined by companies capability to develop the drug but their ability to develop systems that can consistently and reliably produce them at scale

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Since the patient did not have a systemic reaction, a divided dose and local steroid therapy was initially administered

10.1038/nature22314 107 HayanoM.YangW