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doi:10.1056/NEJMoa1909406 McGillion M, Arthur HM, Cook A, et al

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Functionally, MAPKAPK2 overexpression mitigated oxidative damage, restored antioxidant capacity, and attenuated markers of DNA damage and cellular dysfunction, suggesting a cytoprotective role under oxidative conditions

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In line with the role of mTOR as a master metabolic regulator, rapamycin-treated enriched CAR T cells showed significant decrease in basal respiration (Fig