In practical terms, this often pushes people back toward safer, non-pharmacologic options: topical self-tanners (dihydroxyacetone), controlled UV exposure with medical-grade phototherapy when indicated, or simply accepting natural skin tone and focusing on photoprotection
Patients with renal impairment, diabetic retinopathy, or thyroid cancer history require specialized medical evaluation before initiation
If they sat in a hot car for several hours, they may not be
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Gu Y, Sun L, He Y, Yang L, Deng C, Zhou R, et al
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer