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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)

Studies of bariatric surgery patients have documented similar phenomena, where rapid weight changes can temporarily exacerbate joint symptoms before eventual improvement occurs

Loprinzi et al

He also believes creatine is a staple nutrient due to cognitive improvement and longevity benefits such as maintaining muscle strength

MayaJPantDFuYJamesKBatlleCHsuSet al

Activation of the GLP-1R by GLP-1 also results in recruitment of -arrestin-1 (Arr1) and -arrestin-2 (Arr2), which mediate receptor internalization and may serve as scaffolds for G protein-independent signaling ( 18, 19 )