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PLoS One 2013

When taken in high doses or frequently, the demand for glutathione can exceed the body's natural supply

However, discontinuation rates are similar for both treatments (approximately 6%), suggesting that while CagriSema causes more frequent gastrointestinal symptoms, they are generally manageable

GHK-Cu directly stimulates fibroblasts (the cells that produce collagen) to increased synthesis of: Type I collagen , the main structural protein of skin, tendons, ligaments (+70 % in the Maquart 1988 studies) Type III collagen , a more flexible type for regenerative tissues Elastin , the protein responsible for the elasticity of skin Decorin and glycosaminoglycans , hyaluronan, dermatan sulfate In the dermatological area this explains the anti-wrinkle effect of GHK-Cu, restoration of the skins collagen structure, which weakens with age

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