history of glp-1 drugs glp 1 agonists Discovery GLP-1–Based for the Treatment of Obesity Agonists: A Comprehensive Overview – How GLP-1 Drugs Went From

Ferroptosis can be pharmacologically induced through inhibition of system Xc - (e.g., erastin and its derivatives), direct inhibition of GPX4 (e.g., RSL3), or disruption of the FSP1-CoQ10 axis (97, 98)

In these cardiovascular safety trials, in secondary or exploratory analyses, GLP-1 receptor agonists were also shown to reduce macro-albuminuria, an accepted surrogate marker for diabetic kidney disease (DKD), a condition that still represents a major unmet medical need

Ulrich and Jakob, 2019

References 1 AguilarD.DeswalA.RamasubbuK.MannD

Activators and inhibitors of the hydrolysis of glutathione

Reference Galan, N., RN