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In addition, because the tissues in which the GLP-1 receptor is expressed are not limited to the gastrointestinal and pancreatic glands, GLP-1RA can reduce cardiovascular risk in addition to lowering glucose and reducing body weight

While the clinical significance of this interaction remains uncertain, women relying on oral contraceptives for pregnancy prevention should be counseled about the potential for reduced efficacy and may need to consider additional contraceptive methods, particularly during the initial weeks of therapy when gastric emptying delay is most pronounced

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