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It: Binds approximately 7590% of circulating IGF-1 Regulates how much IGF-1 is bioavailable (free to act on tissues) Is produced primarily by the liver, in response to growth hormone signaling - with IGF-1 serving as a key mediator of GHs effects on tissue growth and development Think of IGFBP-3 as a traffic controller: it determines how much of IGF-1s potent growth signal reaches your cells

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doi: 10.3389/fendo.2025.1645041 22 EldorRAvrahamNRosenbergOShpigelmanMGolan-CohenACukierman-YaffeTet al