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Certain anti-obesity drugs, including selective serotonin reuptake inhibitors and naltrexone/bupropion combinations, have been linked to adverse psychological outcomes such as mood alterations and suicidal ideation [69]
Serious adverse events with tirzepatide are rare but include pancreatitis, gallbladder problems, and potential thyroid concerns (based on animal studies)
What the Clinical Trial Evidence Shows Phase 2 trials published in NEJM (2023) reported dose-dependent mean resting heart rate increases of approximately 57 bpm at higher doses
Qiang, J
Hypothyroidism is also common in this population with higher prevalence in women and older adults [14], and in general affecting 30% and 21% of patients with T2D and obesity, respectively [14,15,16,17]
Sheehan D et al
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