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Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme

Granata A, Maccarrone R, Anzaldi M, Leonardi G, Pesce F, Amico F, et al

We only work with manufacturers who adhere to the strictest quality standards using advanced techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for analytical verification

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2.7 m, 3.0 50 mm) using positive-mode electrospray ionization with 1% acetonitrile in H 2 O (containing 0.1% formic acid) for the first 2 min, then a linear gradient of 195% for 9 min and finally 95% acetonitrile for 3 min with a flow rate of 0.6 ml min 1

It is of critical importance that future studies directly evaluate sex-specific effects of these compounds to fully assess their clinical potential