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This immune activation involves an early increase in Ca 2+ influx, leading to the downstream activation of transcription factors that regulate vital immune responses and hormone biosynthesis (Tarkowski et al

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Semaglutide regulates lipid metabolism and polarization in tumor-associated macrophages (TAMs) through the PPARG/ACSL1 signaling pathway, transforming them from an M2 to an M1 polarized state to inhibit tumor progression

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