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At its heart, you climb up the 686 stepszigzagging through nine lush terraces, grand fountains, and sculpted obelisksto the elegant Sanctuary of Our Lady of Remedies, an 18th-century twin-towered baroque chapel, perched high on the hill like a crown

That's where the drug comes in to recalibrate the signals by mimicking one, and sometimes two, key hunger hormones, and re-setting that internal "enough point" that the brain has determined will keep the body from starving