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PGC1 is the master regulator of mitochondrial biogenesis 34 , and we see a small but sustained increase in PGC1 expression in response to 5FU over 72 h treatment (Fig

OkumuraSKonishiYNarukawaMSugiuraYYoshimotoSAraiYet al

This mechanism is more aggressive and tends to produce more pronounced swelling, pain, and inflammation

Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A

Peroxide mediated effects of homocysteine on arterial prostacyclin synthesis