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Indeed, CX3CR1 knockout mice have impaired GSIS, which is also observed in isolated pancreatic islets from these mice ( Nevertheless, we showed that circulating fractalkine levels increased by 7% three months after bariatric surgery, while fractalkine mRNA expression increased by 73% in the vastus lateralis, suggesting that muscle may contribute to the changes in circulating levels ( 3.2 Brain-derived neurotrophic factor Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central and peripheral nervous system, where it acts as a potent neuronal survival factor and modulator of synaptic plasticity ( BDNF has beneficial metabolic effects on skeletal muscle and beta cells ( Figure 2 )

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