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The reported carry-over effects complicate the notion further: if benefits persist into post-treatment placebo nights, [10] then continuous administration has no coherent justification even within the framework the original authors proposed

While this might seem counterintuitive since glucagon raises blood glucose, the combined effect with GLP-1 and GIP agonism keeps glucose levels in check while dramatically increasing the metabolic rate

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In obese or diabetic mice, FGF21 restores the insulin secretion capacity of cells in vivo (261) via several pathways: first, by activating AMPK signaling and autophagy (262)

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