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-cell-selective knockout of the GLP-1R in mice with impaired glucose tolerance after intraperitoneal injection of glucose and exogenous supplementation of GLP-1 did not induce insulin secretion, but glucose tolerance returned to normal after oral glucose, suggesting that the extra-islet GLP-1R plays a regulatory role in oral glucose tolerance (Smith et al., 2014)
Allerdings knnen Stress, Umweltfaktoren oder Alterungsprozesse die Eigenproduktion beeinflussen
Moreover, there are signals of increased incidence of cardiac arrhythmias associated with its use
Excessive production of CRF may lead to bowel dysfunction and VH [78,79,80,81]
