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The effects may last several hours, though some research suggests that the peptides may influence neural pathways for longer through their effects on neurotransmitters and neurotrophic signaling

Methods Mol Biol 846:112

Initial doses are typically conservative to assess tolerability and tissue response before titration upward

Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection