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In those who stopped using GLP-1 compared with those who stayed on the medication, heart risks began to rise several months after stopping: by 4% at six months, by 14% at one year, and by 22% at the second year almost erasing the benefits gained

41 In a meta-analysis of nine RCTs involving 8,920 patients with HF and coexisting T2D, GLP-1 RAs did not improve LVEF, LV end-diastolic volume or LV end-systolic volume

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