Reported Results in Preclinical Models Published rodent work reports reduced white adipose tissue mass in diet-induced obese models under NNMT inhibition, recorded without corresponding changes in food intake
273 Furthermore, a study using the anterior cruciate ligament transection (ACLT) rat model further confirmed that subcutaneous injection of liraglutide at 50 g/kg/day, whether for 3 weeks or 6 weeks, could reduce OARSI scores, highlighting the potential of liraglutide in treating joint degeneration
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However, weight reduction is very difficult to accomplish and maintain