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In preclinical models, it has demonstrated pro-angiogenic, cytoprotective, and anti-inflammatory properties 1-3

[14] Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts

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P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells