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Oxidation of DJ-1 in blood and brain of Parkinsons disease patients- usability as an early diagnosis marker

Treating cells with L-buthionine sulfoximine (BSO), an inhibitor that blocks the synthesis of GSH, renders neuronal SH-SY5Y cells expressing mutant valosin-containing protein (VCP) R487H more susceptible to oxidative stress (Hirano et al., 2015) and increases mutant SOD1 toxicity (Alvarez-Zaldiernas et al., 2016

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Neurotoxicology 29:190201 Muratore CR, Hodgson NW, Trivedi MS, Abdolmaleky HM, Persico AM, Lintas C, De La Monte S, Deth RC (2013)

When OXM was administered over a 4 day period to human subjects there was an observed 10% increase in total energy expenditure