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Four proline residues, including an unusual triple-proline sequence, confer resistance to enzymatic degradation
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Cellular levels of both -Glu-Cys and reduced GSH levels were significantly decreased (Supp Fig 3B), consistent with our hypothesis that the PfMRP1 mutant increases efflux of reduced GSH
Before every injection, hold the syringe needle-up, tap the barrel to move bubbles to the top, and push the plunger gently until a tiny droplet appears at the needle tip
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Additionally, there is a documented increased risk of acute kidney injury in patients who become severely dehydrated due to vomiting or diarrhea, making hydration an important part of any treatment plan
