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This lipid mediator also reduced IL-1, IL-6 and metalloproteinase 3 expression in synovial fibroblasts, while increasing the metalloproteinase inhibitor TIMP1 (147)

Mast cells are immune sentinels that release inflammatory mediators, such as histamine and cytokines, in response to perceived threats

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In a state of mitochondrial dysfunction, partially metabolized fatty acids can build up inside the mitochondria, forming toxic acyl-CoA compounds that inhibit essential enzymes and cause severe oxidative stress

Beck et al

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