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31 The second study enrolled 60 patients with varying degrees of renal impairment and administered 5 mg of oral semaglutide daily for the first 5 days, followed by a 10-mg dose once daily for the remaining 5 days of the study

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This loss of immune ignorance may also rely on other IFN-induced pathways of alternative antigen formation 14,17 , e.g., post-translation modifications (PTMs), alternative transcription start sites generating an INS defective ribosomal product (DRiP) 18 and peptide cis -splicing, i.e., the fusion of non-contiguous protein fragments

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