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Soluble fibre is particularly effective as gut bacteria ferment it into short-chain fatty acids that directly trigger GLP-1 release from intestinal L-cells
Do not attempt to adjust the dose on your own
The dual-pathway mechanism may produce a different experience, but individual responses vary widely
They are no longer used as a first add-on in most NICE pathways but still have a role when cost or specific tolerability concerns make newer drugs unsuitable
Life Sci (2020) 249:117540
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