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This profile not only involves high levels of PAI-1 and STAT3 as previously described, but also includes low levels of glutamine and NAD + , coupled with overproduction of hyaluronan (HA)

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The loss of Glutathione, a vital antioxidant, leads to increased oxidative stress and skin damage

This is the biochemical basis for photoprotection: eumelanin absorbs UV photons before they damage DNA in keratinocytes and melanocytes, reducing reactive oxygen species formation and preventing the inflammatory cascade that causes sunburn

Synergistic Pairings: Vitamin C, NAC (N-acetylcysteine), and milk thistle enhance effects

Vitamin C Vitamin C supports collagen production and helps protect skin cells from oxidative damage