In the long run, this leads to improved health and improved healthspan
44 Yaos meta-analysis of 76 RCTs on GLP-1RAs found a consistent HbA 1c reduction of 2.10% (95% CI [2.47, 1.74%)
Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al
What actually happens is the GLP-1 agonist starts slowing gastric emptying while a large bolus of food is entering the stomach
We found a significant reduction in the GSH/GSSG ratio in the GR-deficient strain compared to the WT strain ( P = 0.0011), indicating severe oxidative stress (Figure 6A)
Blend-specific adverse-effect attribution requires single-component control experiments