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Balancing Weight Loss Benefit With Heart Rate Considerations The cardiovascular benefits of weight lossreduced strain on the heart, improved blood pressure, lower risk of heart diseasetypically outweigh the modest heart rate increase that tirzepatide may cause

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For semaglutide, one could expect a different side-effect profile for the oral versus the subcutaneous formulation

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While this may enhance feelings of fullness, it can also lead to bloating and nausea