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As a result of the functional interdependence between the BBB and the brain, perturbations that promote BBB health generally promote brain health, whereas stresses that result in BBB dysfunction can lead to brain dysfunction
Int J Neuropsychopharmacol
This is the more concentrated option, producing smaller injection volumes for any given dose
The STEP 5 trial demonstrated that while 82% of participants experienced some gastrointestinal event over two years, most occurred during the initial months, with side effect frequency declining substantially in long-term treatment
At a 12 mg maintenance dose, researchers would use 2.4 mL per injection, requiring either larger syringes or split doses