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Basic Clin Neurosci 2024;15:287300

642 Together, ACMSD and NNMT provide novel targets for modulating NAD + homeostasis, which will be of great importance to determine whether ACMSD and NNMT inhibitors can increase NAD + levels and achieve therapeutic effects

Histopathology, muscle weight, and ELISA for nerve growth factor (NGF) were evaluated post-euthanasia

Diet-induced obese (DIO) male rats were treated with (1) vehicle with ad libitum feeding (V), (2) CagriSema with ad libitum feeding (CS), (3) vehicle with pair-feeding matched to the caloric intake of the CS rats (PF) or (4) vehicle with caloric restriction to match the weight of the CS rats (weight matched (WM)) (Fig

(2022) in Cell Metabolism provides the foundational discovery data

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