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Retatrutide is investigational, and unapproved products may contain unsafe or unknown ingredients.

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doi:10.7759/cureus.29696 2

GLP-1 medications at maximum doses produce 15 to 22.5% average weight loss

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Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum