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additive prolongation possible Sertraline CYP involvement / CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 substrate and inhibitor Escitalopram CYP involvement / CYP2C19, CYP3A4 substrate GH axis effect of SSRIs / sertraline and escitalopram can blunt GH response to provocative testing Monitoring interval / baseline ECG recommended when combining

Winkler, B

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Blundell et al