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Thomas, A., Walpurgis, K., Delahaut, P., Fichant, E., Schnzer, W., & Thevis, M

Increased Resistance to Muscular Fatigue

Notably, this protective effect occurred through mechanisms independent of changes in muscle oxidative metabolism or fatigue resistance, distinguishing IGF-1 LR3's mechanism from native IGF-1

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Melatonin is a hormone naturally produced in the pineal gland that primarily regulates the bodys sleep-wake cycle or circadian rhythm

Additionally, clockophagy (selective degradation of aryl hydrocarbon receptor nuclear translocator-like protein 1, a core clock gene) has been reported to enhance ferroptosis sensitivity by disrupting the circadian regulation of lipid metabolism and antioxidant defenses (149)