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This is particularly important when switching from a GLP-1 based therapy to non-GLP-1 options, because the metabolic adjustment can affect blood sugar regulation, blood pressure, and heart rate in ways that warrant monitoring

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Sigma-Aldrich) supplemented with streptomycin (0.1 g/l), penicillin (0.15 g/l), NaHCO3 (3.7 g/l) and 10% fetal bovine serum (FBS