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The functionally active form of thiamine is thiamine pyrophosphate which is involved in the metabolism of carbohydrates as dehydrogenases factor (ketoacidotic branched chain dehydrogenase complex piruvatodeshidrogenasa or alpha-ketoglutarate dehydrogenase) and transcetolasas
Because robust human safety data are limited, it is difficult to give a definitive side-effect profile with meaningful incidence rates
2024 Feb;14(1):e200210
AOD-9604 has been tested in over 900 human participants across six randomized, double-blind, placebo-controlled trials
These symptoms can include a feeling of light-headedness, fatigue, poor recall and memory problems, and even diarrhea or constipation
Higher concentrations of glycochenodeoxycholic acid, glycodeoxycholic acid, hyodeoxycholic acid, and certain bile acid ratios were associated with patient CSF tau and p-tau
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