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Cost Comparison: Real 2026 Numbers A patient paying cash for Zepbound will pay roughly $15,000 per year at pharmacy retail, or about $5,400 per year at LillyDirects $449 self-pay maintenance rate

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Loose Stools: Both can speed up or alter how your digestive tract handles waste

The slowed gut motility responsible for appetite suppression and improved metabolic function does not disappear as your body adjusts

All three mechanisms work toward a healthy regulation of energy in the body

This process is catalyzed by glutathione S-transferase enzymes, which are abundant in liver cells