A randomized, double-blind, cross-over protocol was conducted, entailing the administration of NAC (2g/day) for 60 days and then placebo for another 60 days (or vice versa)
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KarimiMSahandi ZangabadPGhasemiAAmiriMBahramiMMalekzadHet al
In addition, non-neuronal cells residing in both the central nervous system (CNS) and peripheral nervous system (PNS) called glial cells, and among them mainly astrocytes, microglia, and oligodendrocytes provide essential metabolic and functional support to neurons, contributing to their plasticity [238,239,240,241]
In vitro functional analyses confirmed their mature hepatocyte characteristics: they showed high transcription and protein expression of ALB, A1AT, CYP3A4, and CYP2C9, comparable to primary human hepatocytes (PHs)
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