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To bridge these gaps, this review distinguishes itself from prior literature in three key aspects: Firstly, we propose an integrated Gut-Metabolism-Endocrine network model, uniquely positioning gut microbiota dysbiosis as a potential upstream regulator that initiates the systemic OS cascade, rather than merely a secondary symptom

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Review of the epidemiology of T2DM and CKD in various regions worldwide, reporting that the decreasing prevalence of cardiovascular disease results in increased survival, which translates to an increased prevalence of renal complications

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5,384 Although vaccination attempts to eliminate tumor cells overexpressing mutant p53 began more than 20 years ago, currently, no vaccine has been approved for clinical use because various trials have shown no efficacy in patients