This recognition encouraged preclinical studies aiming to investigate both mechanistic aspects and intervention strategies to characterize and target this biological axis in conditions affecting muscle, brain, the immune system, and metabolic diseases
It was shown that the deletion of E155 in GSTO1-1 has a significant effect on enzymatic stability and may consequently alter the physiologic role of the enzyme in the brain regions 53
It also supports mitochondrial flexibility and drives the one-carbon metabolism cycle, making it a cornerstone of metabolic health, epigenetic regulation, and longevity
FAK (focal adhesion kinase) , [3]
At the time of these studies, the roles of reactive oxygen species (ROS) in cells were poorly characterised and information on subcellular compartmentation was at best fragmentary
3l,m), supporting defective FAO