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These compounds have fundamentally different marketing claims than their actual molecular relationship warrants, and neither has an established evidence base from human clinical trials

Cells were incubated overnight to allow adherence before the treatment with eight different antibiotics (doxycycline, rifampicin, moxifloxacin, sparfloxacin, levofloxacin, ciprofloxacin, amoxicillin, and streptomycin) or DMSO as a control

The CONSORT diagram reporting disposition for all 110 enroled participants is shown in Extended Data Fig

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But, as always happens with big pharma blockbusters, the research community is busy exploring other possible applications for this class of compounds, with clinical trials underway or forming in cardiovascular disease, chronic kidney disease and obstructive sleep apnea

Ninety minutes post-injection, animals were anesthetized and perfused for c-Fos immunostaining, a marker of neuronal activation [2]