DPP-4 inhibitors prevent degradation of GLP-1 thereby increasing its systemic concentration
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This is one reason head-to-head binding assays dont always match head-to-head secretion experiments and why researchers occasionally get surprised when GHRP-6 outperforms GHRP-2 in certain model contexts despite lower receptor binding affinity on paper
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10.1016/j.bbrc.2019.01.103 Biochem
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