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NICE guidelines (NG28) recommend GLP-1 receptor agonists for type 2 diabetes based on individual patient factors, including cardiovascular risk, and not strictly as second- or third-line therapy after metformin failure

Diabetologia (2018) 61:81020

Levit, R., Savoy de Giori, G., de Moreno de LeBlanc, A

Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase

Finally, oxidative stress can lead to synovial hyperplasia science-speak for too many cells growing in the joints and cause bone and cartilage damage

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