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Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine

and Ablin, J

2,3 The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb.) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb.) for the placebo group which was statistically significant

Long-term safety data for this combination is limited

A detailed physical exam is mandatory

For post-surgical use: confirm written physician clearance before application