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TRIUMPH-3 was never powered as a cardiovascular outcomes trial
However, the same hormonal action that makes tirzepatide most effective for weight loss often causes significant early side effects, such as nausea and vomiting, during the start of the treatment or during the escalation phase
M., & Burruss, J
You should take Rybelsus with water
Setting realistic expectations early can also prevent unnecessary discontinuation
Daily dosing is generally preferred, based on evidence showing better efficacy and safety than intermittent high-dose regimens
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